Niflumic Acid Activates Additional Currents of the Human Glial L-Glutamate Transporter EAAT1 in a Substrate-Dependent Manner
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چکیده
منابع مشابه
Two non-steroidal anti-inflammatory drugs, niflumic acid and diclofenac, inhibit the human glutamate transporter EAAT1 through different mechanisms.
We investigated the effects of non-steroidal anti-inflammatory drugs on substrate-induced currents of L-glutamate (L-Glu) transporter EAAT1 expressed in Xenopus laevis oocytes. Niflumic acid (NFA) and diclofenac inhibited L-Glu-induced current through EAAT1 in a non-competitive manner. NFA produced a leftward shift in reversal potential (E(rev)) of L-Glu-induced current and increased current am...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2013
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b13-00702